《微生物生理》，《食用菌技术》

主要科研项目：

国家食用菌产业技术体系岗位科学家：《优质栽培生理》，CARS20, 2017.01-2020.12

国家自然科学基金：《转录因子Swi6调控灵芝三萜生物合成的分子机制研究》，编号：31972059，2020.01-2023.12

国家自然科学基金：《灵芝三萜生物合成调控网络中关键基因的克隆及其对茉莉酸甲酯响应机理的研究》，编号：30970042，2010.01-2012.12

国家自然科学基金：《茉莉酸甲酯对灵芝三萜生物合成基因的转录调控作用及调控机理研究》，编号：30871767，2009.01-2009.12

国家自然科学基金：《灵芝鲨烯合酶基因转录调控元件的克隆及其与转录因子结合特性分析》，编号：30571294，2006.01-2008.12

国家自然科学基金：《灵芝鲨烯单加氧酶基因的克隆及其特性研究》，编号：30300006，2004.01-2006.12

江苏省重点研发计划（现代农业）项目：《高黄酮含量桑黄的精准栽培调控技术的研究与集成》，编号：BE2019385，2019年7月-2022年6月。

江苏省农业科技支撑项目：《高黄酮含量桑黄菌种的选育及其生物学特性的研究》，编号：BE2015361，2015年7月-2018年6月。

江苏省农业科技支撑项目：《高三萜灵芝菌种的选育及其生物学特性的研究》，编号：BE2011312，2011年7月-2014年6月。

代表性论文：

1. Liu R., T. Zhu, T. Yang, Z. Y. Yang, A. Ren, L. Shi, J. Zhu, H. S. Yu, M. W. Zhao*, NO regulates ganoderic acid biosynthesis by the S-nitrosylation of aconitase under HS in Ganoderma lucidum, Environmental Microbiology, 2020, 10.1111/1462-2920.15109

2. Hu Y. R., S. S. Hu, W. Z. Xu, J. Zhu, L. Shi, A. Ren, M. W. Zhao*, In Ganoderma lucidum, Glsnf1 regulates cellulose degradation by inhibiting GlCreA during the utilization of cellulose, Environmental Microbiology, 2020, 22(1): 107–121

3. Hu Y. R., W. Z. Xu, S. S. Hu, L. D. Lian, J. Zhu, A. Ren, L. Shi, M. W. Zhao*, Glsnf1-mediated metabolic rearrangement participates in coping with heat stress and influencing secondary metabolism in Ganoderma lucidum, Free Radical Biology and Medicine, 2020, 147: 220–230

4. Zhu J., Z. H. Sun, S. Q. Song, D. K. Shi, L. D. Lian, L. Shi, A. Ren, H. S. Yu, M. W. Zhao*, Dual function of AreA, a GATA transcription factor, in influencing ganoderic acid biosynthesis in Ganoderma lucidum, Environmental Microbiology, 2019, 21(11):4166-4179

5. Hu Y. R., S. S. Hu, W. Z. Xu, J. Zhu, L. Shi, A. Ren, M. W. Zhao*, In Ganoderma lucidum, Glsnf1 regulates cellulose degradation by inhibiting GlCreA during the utilization of cellulose, Environmental Microbiology, 2019, DOI: 10.1111/EMI.14826

6. Liu R.※, P. F. Cao※, A. Ren, S. L. Wang, T. Yang, T. Zhu, L. Shi, J. Zhu, A. L. Jiang, M. W. Zhao*, SA inhibits complex III activity to generate reactive oxygen species and thereby induces GA overproduction in Ganoderma lucidum, Redox Biology, 2018, 16: 388-400

7. Liu Y. N., X. X. Lu, A. Ren, L. Shi, J. Zhu, A. L. Jiang, H. S. Yu, M. W. Zhao*, Conversion of phosphatidylinositol (PI) to PI4-phosphate (PI4P) and then to PI (4,5) P2 is essential for the cytosolic calcium concentration under heat stress in Ganoderma lucidum, Environmental Microbiology, 2018, 20(7): 2456–2468

8. Gao T. ※, L. Shi※, T. J. Zhang, A. Ren, A. L. Jiang, H. S. Yu, M. W. Zhao*, Cross-talk between calcium and ROS regulates hyphal branching and ganoderic acids biosynthesis in Ganoderma lucidum under copper stress, Applied and Environmental Microbiology, 2018, 84(13) : e00438-18

9. Liu R.※, L. Shi※, T. Zhu, T. Yang, A. Ren, J. Zhu, M. W. Zhao*, Cross-talk between nitric oxide and calcium-calmodulin to regulate GA biosynthesis in Ganoderma lucidum under heat stress, Applied and Environmental Microbiology, 2018, 84(10) : e00043-18

10. Liu Y. N., X. X. Lu, C. Dai, Y. P. Lu, A. Ren, L. Shi, J. Zhu, A. L. Jiang, H. S. Yu, M. W. Zhao*, Phospholipase D and phosphatidic acid mediate heat stress induced secondary metabolism in Ganoderma lucidum, Environmental Microbiology, 2017, 19(11), 4657–4669,

11. Liu Y. N., T. J. Zhang, X. X. Lu, B. L. Ma, A. Ren, L. Shi, A. L. Jiang, H. S. Yu, M. W. Zhao*, Membrane fluidity is involved in the regulation of heat stress induced secondary metabolism in Ganoderma lucidum, Environmental Microbiology, 2017, 19(4): 1653–1668 ,

12. Ren A.※, R. Liu※, Z. G. Miao※, X. Zhang, P. F. Cao, T. X. Chen, C. Y. Li, L. Shi, A. L. Jiang, M. W. Zhao*, Hydrogen-rich water regulates effects of ROS balance on morphology, growth and secondary metabolism via glutathione peroxidase in Ganoderma lucidum, Environmental Microbiology, 2017, 19(2): 566–583,

13. Wu C. G., J. L. Tian, R. Liu, P. F. Cao, T. J. Zhang, A. Ren, L. Shi, M. W. Zhao*, Ornithine decarboxylase mediated production of putrescine influences ganoderic acid biosynthesis via the regulation of ROS in Ganoderma lucidum, Applied and Environmental Microbiology, 2017, 83(20): e01289-17

14. Han Q.※, F. L. Wu※, X. N. Wang, H. Qi, L. Shi, A. Ren, Q. H. Liu, M. W. Zhao* and C. M. Tang*, The bacterial lipopeptide iturins induce Verticillium dahliae cell death by affecting fungal signaling pathways and mediate plant defence responses involved in pathogen-associated molecular pattern-triggered immunity, Environmental Microbiology, 2015, 17(4), 1166–1188

15. Mu D. S., C. Y. Li, X. C. Zhang, X. B. Li, L. Shi, A. Ren, and M. W. Zhao*, Functions of the nicotinamide adenine dinucleotide phosphate oxidase family in Ganoderma lucidum: an essential role in ganoderic acid biosynthesis regulation, hyphal branching, fruiting body development, and oxidative-stress resistance, Environmental Microbiology, 2014, 16(6), 1709–1728,